Milk Thistle Extract 250mg

Milk thistle (Silybum marianum) extract is one of the most researched hepatoprotective botanicals. Each capsule delivers 250mg of standardized extract containing 80% silymarin – a mixture of flavonolignans (silybin, isosilybin, silychristin, silydianin). Silybin is the most active constituent, shown to: stabilize hepatic cell membranes, stimulate protein synthesis (regeneration), act as an antioxidant (increase glutathione levels), and reduce inflammation (inhibit NF-κB). Clinical applications: non-alcoholic fatty liver disease (reduces ALT/AST by 20-40%), alcoholic liver disease, drug-induced liver injury (acetaminophen, antipsychotics, statins), and cirrhosis. 180 capsules – three-month supply (two capsules daily). Take one capsule twice daily with meals. Safety: Very low toxicity; may cause mild laxative effect. Potential interaction with cytochrome P450 2C9 substrates (diazepam, warfarin) – monitor INR. Avoid in estrogen-sensitive cancers (theoretical concern).